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Akiko Okamoto Selected Research

Tapentadol

8/2013Bowel function after tapentadol and oxycodone immediate release (IR) treatment in patients with low back or osteoarthritis pain.
9/2012Pharmacokinetic and pharmacodynamic modeling of opioid-induced gastrointestinal side effects in patients receiving tapentadol IR and oxycodone IR.
5/2011Comparable efficacy and superior gastrointestinal tolerability (nausea, vomiting, constipation) of tapentadol compared with oxycodone hydrochloride.
1/2011Safety and efficacy of tapentadol ER in patients with painful diabetic peripheral neuropathy: results of a randomized-withdrawal, placebo-controlled trial.
8/2010Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study.
6/2010Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain.
5/2010Evaluation of study discontinuations with tapentadol inmmediate release and oxycodone immediate release in patients with low back or osteoarthritis pain.
1/2010Efficacy and safety of Tapentadol extended release compared with oxycodone controlled release for the management of moderate to severe chronic pain related to osteoarthritis of the knee: a randomized, double-blind, placebo- and active-controlled phase III study.
1/2010Dose conversion between tapentadol immediate and extended release for low back pain.
7/2009Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule.
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Akiko Okamoto Research Topics

Disease

13Pain (Aches)
10/2020 - 11/2008
10Neoplasms (Cancer)
06/2020 - 02/2010
9Nausea
09/2012 - 11/2008
8Autoimmune Diseases (Autoimmune Disease)
06/2015 - 08/2004
8Vomiting
09/2012 - 11/2008
7Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2014 - 10/2008
7Constipation
08/2013 - 11/2008
5Breast Neoplasms (Breast Cancer)
06/2020 - 01/2015
5Osteoarthritis
08/2013 - 05/2009
5Rheumatoid Arthritis
07/2013 - 01/2006
5Arthritis (Polyarthritis)
01/2011 - 01/2006
4Acute Pain
01/2015 - 11/2008
4Prostatic Neoplasms (Prostate Cancer)
04/2012 - 03/2008
4Low Back Pain (Lumbago)
08/2010 - 05/2009
3Chronic Pain
10/2020 - 01/2010
3Urinary Bladder Neoplasms (Bladder Cancer)
02/2013 - 01/2008
3Nephritis
11/2012 - 09/2007
3Dizziness (Lightheadedness)
01/2011 - 11/2008
3Experimental Arthritis
01/2011 - 01/2006
2Systemic Scleroderma (Systemic Sclerosis)
01/2016 - 01/2011
2Neoplasm Metastasis (Metastasis)
03/2015 - 07/2013
2Postoperative Pain
01/2015 - 11/2008
2Pheochromocytoma
07/2013 - 10/2010
2Thrombotic Microangiopathies
07/2011 - 01/2011
2Hypertension (High Blood Pressure)
05/2011 - 01/2011
2Knee Osteoarthritis
06/2010 - 01/2010
2Sleepiness
05/2009 - 11/2008
1Carcinoma (Carcinomatosis)
03/2022
1Lymphoma (Lymphomas)
11/2021
1Phyllodes Tumor (Cystosarcoma Phylloides)
11/2021
1Margins of Excision
06/2020
1Lobular Carcinoma
06/2020
1Overactive Urinary Bladder (Overactive Bladder)
01/2020
1Albuminuria
01/2020
1Thrombosis (Thrombus)
03/2016
1Obesity
03/2016
1Neutropenia
03/2015
1Macular Degeneration (Age-Related Maculopathy)
01/2015
1Renal Cell Carcinoma (Grawitz Tumor)
11/2013

Drug/Important Bio-Agent (IBA)

14TapentadolFDA Link
08/2013 - 11/2008
11Oxycodone (Oxycontin)FDA LinkGeneric
08/2013 - 11/2008
5AutoantibodiesIBA
01/2011 - 09/2007
4AutoantigensIBA
06/2015 - 08/2004
4Proteins (Proteins, Gene)FDA Link
01/2011 - 01/2009
4Nucleosomes (Nucleosome)IBA
10/2008 - 08/2004
3Analgesics (Analgesic Drugs)IBA
01/2015 - 11/2008
3Opioid Analgesics (Opioids)IBA
01/2015 - 01/2011
3CytokinesIBA
01/2013 - 11/2007
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2010 - 01/2006
2N 30IBA
03/2013 - 01/2011
2GemcitabineFDA Link
02/2013 - 01/2008
2Messenger RNA (mRNA)IBA
02/2013 - 01/2006
2Carboplatin (JM8)FDA LinkGeneric
02/2013 - 01/2008
2Complementary DNA (cDNA)IBA
01/2013 - 09/2010
2Biological ProductsIBA
01/2013 - 12/2006
2AntigensIBA
11/2007 - 03/2007
2Risperidone (Risperdal Consta)FDA LinkGeneric
05/2004 - 07/2002
1PlatinumIBA
03/2022
1diclofenac hydroxyethylpyrrolidine (DIEP)FDA Link
10/2020
1CreatinineIBA
01/2020
1ErbB Receptors (EGF Receptor)IBA
01/2017
1Trastuzumab (Herceptin)FDA Link
01/2017
1AnthracyclinesIBA
01/2017
1Taxoids (Taxanes)IBA
01/2017
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2017
1Docetaxel (Taxotere)FDA Link
01/2017
1Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric
03/2016
1HLA Antigens (Human Leukocyte Antigens)IBA
01/2016
1Bevacizumab (Avastin)FDA Link
03/2015
1Paclitaxel (Taxol)FDA LinkGeneric
03/2015
1Retinaldehyde (Retinal)IBA
01/2015
1Interferon Regulatory Factor-2 (Interferon Regulatory Factor 2)IBA
01/2014
1Tyrosine Kinase InhibitorsIBA
11/2013
1Axitinib (AG 013736)IBA
11/2013
1LaxativesIBA
08/2013
1Adrenocorticotropic Hormone (ACTH)FDA Link
07/2013

Therapy/Procedure

16Therapeutics
01/2017 - 08/2004
4Drug Therapy (Chemotherapy)
03/2022 - 02/2013
4Renal Dialysis (Hemodialysis)
01/2013 - 10/2010
3Immunotherapy
03/2022 - 08/2004
3Lymph Node Excision (Lymph Node Dissection)
07/2013 - 03/2008
3Adrenalectomy
07/2013 - 10/2010
3Prostatectomy (Retropubic Prostatectomy)
04/2012 - 03/2008
2Simple Mastectomy
10/2020 - 06/2020
2Analgesia
01/2015 - 03/2009
2Combination Drug Therapy (Combination Chemotherapy)
02/2013 - 01/2008
2Gastrectomy
11/2010 - 03/2008
2Lasers (Laser)
01/2010 - 01/2009
2Orthopedic Procedures
06/2009 - 03/2009
1Mastectomy (Mammectomy)
11/2021
1Breast Implants (Breast Implant)
11/2021
1Perforator Flap
10/2020
1Tissue Expansion Devices (Tissue Expander)
10/2020
1Mammaplasty (Breast Reconstruction)
10/2020
1Segmental Mastectomy (Lumpectomy)
06/2020
1Conservative Treatment
06/2020
1Neoadjuvant Therapy
01/2017
1Molecular Targeted Therapy
03/2016
1Palliative Care (Palliative Therapy)
03/2016
1Thyroidectomy
07/2013